There are a lot of variables involved in the answer you are seeking. the best answer I can give you, is to go out and shoot the rifle, and see where your poi is. The hash marks, mil dots, in the scope are only a general indication of where your bullet will impact the target at any given range. I had my Leupold, VXII, with long range varmint reticle, customized by Leupold, just for my 204. I had to give them the caliber of the bullet, the weight of the bullet, the velocity it was traveling, the ballistic coefficient, the altitude, where I do most of my shooting, and even an average temp we shoot in. This system is designed to be sighted in at 100yds. This works out really well for me, because most of the time, I shoot the same bullet, at the same velocity, in the same place. Even when I went 100 miles away to a different place, to shoot, the system still worked out, because temps were about the same and the elevation was almost identical. So unless your ballistic plex is setup for the load you are shooting, it will only get you in the general area.
[b]NRA Benefactor Life member
[i]HOWA 1500 Varmint 204 Ruger, Bull Barrel, Hogue Overmold Stock, Leupold VXII 6-18x40mm AO LRV Custom Reticle Timney Trigger
Cooper Mdl 21 20VarTargW/Leupold VXIII, 6-20x40AO Varmint Hunter reticle.